As far as data goes you’ll be fine, power is another story.
I have used a number of addressable pixel strings in both WS281x and SK681x(W) formats.
They have been predominately at lower densities than yours, typically 10leds/m.
I try and power my strips from the middle outward so that the drops for each string are split into two pieces that are each half of what the whole string would force.
For 5V strings, the worst case has been SK6812 RBGW.
A 5M string powered from the center needs ~3A of current and sees a drop of .5V at each end.
A 12V string (again 10leds/m) powered from the center, sees a drop of .35V at each end.
Given the lower drop of the 12V strings, I can safely run 10m 12V (2x5m pieces) strings powered at their central junction and see less than 1V drop at the ends.
All of this is highly dependent on the gauge of wire that interconnects the LED’s in a string. For my strings it tends to be 20AWG or sometimes 18AWG. Strips may do better (or worse) for higher densities. Unfortunately you won’t really know until you can try your product.
One technique I use often (and highly recommend) is to run a continuous “high voltage” bus in parallel with the main string and attach modular buck converters at your injection points. That lets you supply lower current over the bus line (due to the higher voltage) and drop it to the voltage the string needs at the injection points. I’ve done 600 LED’s over 30m using a 24V bus with 5V converters as needed.
I don’t see you getting away from some power injection over a run that long. At absolute minimum you’ll need some fairly heavy wire to try and transport the total current load. In the real world I settled on a reasonably small wire (2C-18AWG stranded is available in some really small jacket sizes) with lower voltage drops at the current I need.
Note that my bus does indeed experience voltage drops as well, but I’m much less worried about a 5V drop on a 24V line when my end goal is to get through a 5V converter. The downside is you end up using a larger power supply than you might otherwise need but you never worry about voltage drops at the string.