Awesome that Hyperion supports TPM2 net!
It is to be expected that it is not as smooth, it has to handle a lot more packets!
I’m not sure if the definition of packet size is in bytes or in # of LEDs, with or without TPM2 header, but you could give packet sizes 381, 387, 1143 and 1149 a try. One of them might make your setup a little bit smoother by reducing the amount of packets that need to be received 