The only comment I can give is that it looks absolutely amazing, and admire the skills that you can design your own device like that. I Have a built circuits but never on a PCB. Is it very different? Is there software you can recommend? Which one did you use? The 3d model and render must be most helpful in the design process. Can you have these then produced based on the export files/blueprint in a facility? I think it’s smart you left out the mic and went for the line-in. After all WLED accepts external API calls and has support for a wide range of protocols.
One I would consider is adding a suitable antenna if it is going to be used wirelessly because the default esp32 don’t have a long range and are very susceptible to interferance. Alternatively you could think of adding support for an Ethernet connection, such as the ABC! board extension I just bought.
Look forward to seeing how this progresses!